Abstract 4051: Adiponectin, Metabolic Syndrome and Subclinical Atherosclerosis
Background: Persons with the metabolic syndrome (MetS) have lower levels of adiponectin and increased levels of coronary calcium, a measure of subclinical atherosclerosis. We investigated the inter-relationships between adiponectin, metabolic syndrome, and vascular calcification.
Methods: 1384 individuals (mean age 59.2 years, 53% male) who underwent CT scanning for evaluation of coronary artery calcium (CAC) and thoracic aortic calcium (TAC) were classified according to presence of MetS (26.2%) by National Cholesterol Education Program criteria, or diabetes (DM) (8.5%). Adiponectin measures were performed by sandwich immunoassay (Biosite, Inc). Analysis of covariance and multiple logistic regression examined relationships of adiponectin and MetS / DM with any (score >0) and significant (score>=400) CAC and TAC.
Results: Age and risk-factor adjusted mean adiponectin levels were significantly lower in those with MetS (excluding DM) (5104 ng/ml) or DM (6101 ng/ml) compared to those without these conditions (8318 ng/ml) (p<0.001); however, there were no significant differences across levels (scores of 0, 1–99, 100–399, and 400+) of CAC (mean adiponectin levels: 7023, 7412, 7611, and 7778 ng/ml, respectively) and TAC (mean adiponectin levels: 7411, 6862, 7545, and 7147 ng/ml, respectively). Multiple logistic regression showed DM to be associated with an increased odds (OR) of any CAC (OR=3.0, p<0.001), significant CAC (OR=2.6, p<0.01), and significant TAC (OR=2.6, p<0.01) and MetS to be associated only with any TAC (OR=1.3, p<0.05); however, adiponectin levels (standardized, or lowest quartile) were not associated with any or significant CAC or TAC. Interaction terms of adiponectin and MetS / DM did not suggest an effect of adiponectin levels on modifying the relationships of MetS / DM with CAC or TAC.
Conclusions: While adiponectin levels are significantly lower in those with MetS or DM compared to those without these conditions, they are not associated with vascular calcification, and associations of MetS / DM with vascular calcification are not affected by adiponectin levels. Longitudinal investigations are needed to examine if there is a role for adiponectin levels in promoting atherosclerosis in persons with and without MetS / DM.