Abstract 4005: Comparison between Adiponectin and Leptin Regarding Their Relationship to Metabolic Syndrome
Introduction: Two representative adipokines, adiponectin and leptin, have been suggested to play important roles in the pathogenesis of metabolic syndrome (MetS). However, little information exists on their respective features in relation to MetS.
Hypothesis: Adiponectin and leptin are distinctly associated with each MetS component and its clustering.
Methods: We studied 2805 middle-aged Japanese men without a history of cancer or cardiovascular disease. Since it was less likely that changes in these adipokines cause an increase in adiposity, we focused on the association of adiponectin or leptin with 4 MetS components other than central obesity. Thus, we computed odds ratios (ORs) in favor of the presence of each MetS component or its clustering (≥2 components) according to a 1-SD decrease in log-adiponectin and a 1-SD increase in log-leptin with multivariate logistic regression analyses, in which both adipokines were entered as explanatory variables simultaneously.
Results: Both adipokines were equally associated with hypertriglyceridemia and hyperglycemia, in terms of the individual MetS components (Table⇓). Interestingly, adiponectin had a closer association than leptin with low high-density lipoprotein cholesterol (HDL-C). In contrast, the association with elevated blood pressure was only significant for leptin. As a result, both adipokines were independently and significantly associated with the clustering of 2 or more MetS components. These results were not altered even after adjustment for body mass index.
Conclusion: Both adiponectin and leptin were independently associated with MetS. However, decreased adiponectin seemed to play a greater role in the reduction of HDL-C. So did increased leptin in the elevation of blood pressure. These data may have important implications both for inferring the etiological role of these adipokines causing MetS and for introducing them as targets for MetS treatment.