Abstract 3986: Migraines, ST Depression and Risk for Cardiac Events: Results from the MIMS Study
Background: Migraine is a common problem affecting millions of Americans. Women are more likely to have migraines than men. The current study investigates the relationship between migraine, ischemia and cardiac events in older women.
Methods: The Myocardial Ischemia and Migraine Study (MIMS) was a multi-center ancillary study of the Women’s Health Initiative which recruited 3369 postmenopausal women (aged 50 - 79), who completed a series of questionnaires and underwent 24 hour ambulatory ECG-monitoring (AECG). The prevalence of myocardial ischemia as indicated by the presence of ST segment depression, and the number, duration and severity of ST events were compared in women with and without migraine using Chi-squared and t-tests. Cox proportional hazards models provided hazard ratios (HR) and 95% confidence intervals for migraine and composite of cardiac events [Myocardial Infarction, death, coronary artery bypass graft, hospitalized angina, & percutaneous transluminal coronary angioplasty] subsequent to AECG, controlling for multiple covariates (age, race, body mass index, smoking, hypertension, diabetes, and cardiovascular disease history).
Results: The Migraine Status Questionnaire, obtained at the time of ambulatory ECG monitoring, available for 3341 individuals, indicated that 476 (14%) participants experienced migraine. Individuals who experienced migraine were younger, more likely to be Caucasian or Hispanic than African-American or Asian/Pacific Islander, less like to have diabetes and more likely to have a previous cardiovascular disease diagnosis than those who did not experience migraine (p<.01). Migraine and no-migraine participants were similar in body mass index, tobacco use and hypertension history. There were no significant differences between migraine and no-migraine participants on any measure of ST-depression. HRs for migraine indicated no significant relationship to events (HR .86, 95% .51 to 1.45). HRs for migraine with compared to without auras were also non-significant (HR 1.57, 95% CI: .69 - 3.61).
Conclusions: The results of this study suggest that women with migraine are not more likely than those without migraine to experience either ST depression or cardiac events during an average four years follow-up.