Abstract 3978: Smoking Cessation is Associated with Increased Plasma Levels of Adiponectin in Men with Stable Effort Angina
Background: Adiponectin has been identified as a representative marker of metabolic syndrome, and decreased levels of adiponectin are known to be associated with coronary artery disease and future incidence of myocardial infarction. Cigarette smoking is one of the major risk factors for atherosclerotic disease, and recent observations showed that smoking habit may be associated with reduced plasma levels of adiponectin. However, the influence of smoking cessation on plasma adiponectin levels remains to be elucidated. We hypothesized that cessation of cigarette smoking is associated with increased plasma levels of adiponectin.
Methods and Results: Fifty-eight men (39 non-smokers and 19 current smokers) with stable effort angina who underwent coronary stent implantation were investigated. We measured plasma adiponectin levels at coronary intervention and those after 6 months. There were 12 men who successfully quit smoking for 6 months. Plasma adiponectin levels at coronary intervention were comparable to those after 6 months in non-smokers (4.12 [3.02 to 6.26] vs 4.58 [2.90 to 6.26] μg/mL, p=0.143) and in continuous smokers (4.78 [3.77 to 9.64] vs 5.19 [4.00 to 7.48] μg/mL, p=0.866). Meanwhile, the increase of adiponectin level was observed by cessation of cigarette smoking for 6 months (4.06 [2.81 to 4.84] vs 4.86 [3.80 to 6.95] μg/mL, p=0.008). Univariate analysis revealed that the percent increase of adiponectin levels was positively correlated with smoking cessation (p=0.014), percent increase of high density lipoprotein cholesterol levels (p=0.163), additional use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers (p=0.072) and negatively correlated with additional use of β-blockers (p=0.034). A multivariate analysis demonstrated that smoking cessation was a significant and independent determinant of the increase of adiponectin levels (p=0.047).
Conclusions: Smoking cessation is significantly associated with increased plasma adiponectin levels in men with stable effort angina. Our results suggest that the significance of smoking cessation may be in part demonstrated by the increase of plasma adiponectin and it may bring better clinical outcomes in patients with metabolic syndrome.