Abstract 3973: Gastric Bypass Surgery Improves Inflammatory, Structural, and Functional Markers of Coronary Atherosclerosis
Introduction: Although obesity is known to be a risk factor for the development of coronary atherosclerosis, a significant number of morbidly obese patients cannot maintain a meaningful long-term weight loss program. Roux-en-Y gastric bypass surgery (GBS) is a successful surgical treatment of morbid obesity. The effects of GBS on carotid intima-media thickness (CIT) and brachial flow mediated dilation (FMD) are unknown.
Hypothesis: We assessed the hypothesis that GBS would favorably affect risk factors and markers of coronary atherosclerosis including: CIT, FMD, C-reactive protein (CRP), total cholesterol, LDL- cholesterol, and triglycerides.
Methods: 50 patients with morbid obesity scheduled for GBS underwent measurement of CIT, FMD, CRP, total cholesterol, LDL- cholesterol, and triglycerides prior to and 6 months after GBS. CIT and FMD were measured with standard ultrasonographic techniques. Mean ± SEM Pre-GBS and Post- GBS measurements of these parameters were statistically compared using a two-tailed paired Student’s t-test.
Results: See table⇓ for data and statistical analysis
Conclusion: GBS results in a significant improvement in inflammatory, structural, and functional markers of atherosclerosis as early as 6 months following surgery. Given the predictive value of these markers, GBS should be regarded as having a substantial and favorable risk modification effect on coronary atherosclerotic events.