Abstract 3970: Obesity and risk of Type 2 Diabetes in UK Indian Asians and Northern Europeans in the London Life Sciences Population (LOLIPOP) study
Background Type 2 Diabetes (T2D) prevalence is 3 fold higher amongst UK Indian Asians (IA) than Northern Europeans (NE). We have examined the contribution of obesity to T2D prevalence in IA compared with NE, among participants in the London Life Sciences Population (LOLIPOP) Study.
Methods The LOLIPOP study is a population based study of IA and NE men and women aged 35–75 years, identified from the lists of 58 Primary Care Physicians in West London. To date 19,272 participants (IA: 8791 male, 4013 Female; NE: 4346 male, 2122 female) have been recruited, with a response rate of 61%. Clinical and anthropometric data, including waist-hip girth ratio (WHR), waist circumference (Waist) and body mass index (BMI), and fasting glucose were recorded for each subject.
Results T2D prevalence was higher in IA men and women compared with respective NE (table⇓). IA men had higher WHR, similar Waist but lower BMI compared to NE men. In contrast, WHR, Waist and BMI were all higher in IA women compared with NE women. WHR, Waist and BMI were each associated with risk of T2D in and NE. Numerically WHR higher by 0.01, waist circumference by 1cm, and of BMI by 1kg/m were associated with a 7%, 4% and 9% higher risk of T2D respectively, and these relationships were similar in all 4 groups. After adjustment for age and gender, T2D was 3.6 fold more common in IA than NE (P<0.001). Following additional adjustment for WHR, waist circumfer ence and BMI the risk of T2D in IA compared to NE remained elevated at 3.0, 3.6 and 3. respectively (all P<0.001).
Conclusions T2D prevalence is three fold higher in IA than NE WHR, waist circumference and BMI are each associated with risk of T2D in IA and NE. However these markers of obesity only account for a small proportion of the increased risk of T2D in IA