Abstract 3966: Metabolic Syndrome Is a Prognostic Risk in Patients with Diastolic Heart Failure
Background: Metabolic syndrome (MS) is an important risk for cardiovascular diseases, which may culminate in the development of chronic heart failure (CHF). However, little is known regarding the relationship between MS and the prognosis of patients with diastolic heart failure (DHF). The present study was designed to evaluate the prognostic impact of MS on DHF patients using our CHF database (n=1,278).
Methods: The study population was 312 patients with DHF. MS was defined using the Third Report of the National Cholesterol Educational Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Obesity was defined as body mass index (BMI)≥ 25. The association between MS and the prognosis of patients was evaluated using Kaplan-Meier analysis and Cox regression analysis, which were adjusted by age and DHF etiology.
Results: The prognosis of DHF patients with MS was significantly poorer (Figure A⇓), although each single component of MS, such as obesity, hyperglycemia (HG), hypertension (HT), or dyslipidemia (DL), was not significantly related with the prognosis of DHF patients (Figure B⇓). Furthermore, MS including obesity and any two of HG, HT, or DL was the significant prognostic risk in DHF patients (Figure B⇓).
Conclusion: MS is an important prognostic factor in patients with DHF as well. Further investigation is necessary to improve prognosis and quality of life in those patients.