Abstract 3928: Impact of Asymptomatic and Symptomatic End Organ effects of Diabetes Mellitus on the Quality of Life in The Bypass Angioplasty Revascularization Investigation of Type 2 Diabetes (BARI 2D)
Background: End-organ effects of diabetes and atherosclerotic disease are hypothesized to have a significant impact on functional status. The influence of both symptomatic and asymptomatic end-organ effects were evaluated.
Methods: A total of 2321 subjects enrolled in the BARI 2D trial with type 2 diabetes and coronary artery disease were analyzed. The Duke Activity Score Index (DASI) was measured at study entry with higher scores reflecting greater activity level. Asymptomatic and symptomatic end organ effects included the Ankle-Brachial Index, Glomerular Filteration Rate (GFR), Albumin to Creatinine ratio (ACR), Michigan Neuropathy Screening Index (MNSI), stroke, retinopathy requiring laser treatment, angina class and erectile dysfunction.
Results: Mean age was 62 ± 9 years, Males 70%, h/o MI 32%, COPD 5%. Ethnic distribution was: White 66%, Black 17%, Hispanic 13%, and Asian 4%. The mean DASI was 19±14. The association between common asymptomatic and symptomatic end-organ effects of diabetes and functional status is shown.
Conclusions: In the BARI 2D study, the functional status of diabetes patients is influenced not only by symptomatic end-organ damage caused by diabetes mellitus but also by its asymptomatic effects. Understanding the relative contribution of these end-organ effects on quality of life permits patient-specific assessment to identify which end-organ effects are most disabling.