Abstract 3907: Favorable Risk Factor Profile (Low Risk) and Markers of Inflammation: The Multi-Ethnic Study of Atherosclerosis (MESA)
Background: There is evidence indicating that, in addition to established CVD/CHD risk factors, higher levels of inflammatory factors are associated with poorer health and subsequent morbidity, disability, and mortality. Information is lacking on the relationship of having favorable levels of all major CVD/CHD risk factors (low-risk, LR) with levels of inflammatory biomarkers.
Objective and Methods: Assess the relations of LR and markers of inflammation among 5,696 MESA participants ages 45–84, men and women of diverse ethnicity and education levels, and free of clinical CVD and major ECG abnormalities. LR was defined as SBP/DBP ≤120/≤80 mmHg, serum cholesterol <200 mg/dL, no meds for BP or lipids, BMI <25 kg/m2, no diabetes, not smoking; those above LR had 0 RF, 1RF, or 2+RF of the following: SBP ≥140 or DBP ≥90 mmHg or taking BP meds, serum cholesterol ≥240 mg/dL or taking meds for cholesterol, BMI ≥30 kg/m2, diabetes, or smoking.
Results: About 7% of the cohort was LR. Compared to others, higher proportions of LR persons were <65 years (59%), females (57%), whites (45%), and more educated (76% had more than high school [HS] education). Multivariate-adjusted mean levels of inflammatory markers, c-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, tumor necrosis factor alpha (TNF-α) receptor-1, e-selectin, and intercellular adhesion molecule-1 (ICAM1), were significantly lower for LR persons compared to those with 0RF, 1RF, or 2+RF (P-trends <0.001) (Table⇓). Similar patterns were observed in stratified analyses by age (<65 and ≥65 years), gender, race (Whites, Blacks, Hispanics, and Chinese), or education (HS graduate or less and more than HS graduate) (P-trends 0.01 to <0.001).
Conclusions: After controlling for multiple risk factors, asymptomatic adults with favorable levels of all major risk factors had lower levels of inflammatory markers. While these data are cross-sectional, they represent a potentially important finding for CHD/CVD prevention.