Abstract 3886: Alcohol Consumption and Risk of Stroke among Chinese Men
The relationship between alcohol consumption and risk of stroke has not been well characterized in Asian populations. We examined the relationship between alcohol intake and risk of stroke among a population-based cohort of 68,036 Chinese men ≥40 years who were free of stroke at baseline. Frequency and type of alcohol consumed were collected at baseline examination in 1991 using a standard protocol. Follow up evaluation was conducted in 1999–2000, which included determining vital status, interviewing participants or proxies and obtaining hospital and medical records for incident and fatal strokes. Over the course of 522,960 person-years of follow-up, we documented 3,553 incident (1,896 fatal) strokes. After adjustment for age, body mass index, physical activity, urbanization (urban vs. rural), geographic variation (North vs. South), hypertension, cigarette smoking, diabetes, and education, compared to nondrinkers, relative risk (95% confidence interval) of stroke incidence was 0.87 (0.76–1.01) for participants consuming 1 to 6 drinks/week, 1.00 (0.90–1.10) for those consuming 7 to 20 drinks/week, 1.20 (1.05–1.36) for those consuming 21 to 34 drinks/week, and 1.23 (1.10–1.38) for those consuming 35 or more drinks per week. The corresponding relative risks for stroke mortality were 0.92 (0.75–1.13), 0.94 (0.82–1.08), 1.09 (0.90–1.31), and 1.20 (1.03–1.39) respectively. P-value for a “J-shaped” association was statistically significant for both incidence and mortality. These results suggest that moderate alcohol consumption may decrease risk of stroke, while heavy alcohol consumption may increase the risk of stroke in Chinese men.