Abstract 3885: Alcohol Consumption and 12-Year Risk of Stroke by Subtype in Korean Men: Korea Medical Insurance Corporation Study
Background: Several studies suggest that moderate alcohol consumption may reduce risk of stroke. However stroke is composed of several subtypes, and they have different pathogeneses and risk factor profiles. We prospectively investigated the relationships between alcohol consumption and risks of stroke subtypes, including ischemic stroke, intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH).
Methods: We measured body mass index, blood pressure, fasting glucose, total cholesterol in 1990 and 1992, and asked about smoking and alcohol drinking habits in 1992, for 108461 men who were aged 35–59 years. Primary outcomes were hospital admission and deaths from strokes from 1993 through 2004. Independent relationships between alcohol intake and stroke subtypes were assessed using Cox’s proportional hazard models.
Results: During the 12 years, 3083 strokes (1840 ischemic, 686 ICH, 230 SAH, and 327 unclassified) were observed. There was a U-shaped association between alcohol consumption and risk of stroke, and the risk was lowest among men who consumed 20–39 grams of alcohol per day. However the relationships differed by stroke subtypes. For ischemic stroke, alcohol consumption had a negative association until 80 g/day. There was a positive linear trend between alcohol consumption and ICH. No significant association was observed between alcohol consumption and SAH.
Conclusions: Moderate alcohol consumption is associated with reduced risk of stroke, specifically ischemic subtype, in Korean men. But higher consumption of alcohol may cause excess risk of ICH.