Abstract 3884: Left Ventricular Mass Index Independently Predicts Incident Stroke in African Americans: the Atherosclerosis Risk in Communities Study
Background: No large population-based study has examined in detail the relation of echocardiographic left ventricular mass index (LVMI) to incident stroke in African Americans despite the higher prevalence of LV hypertrophy (LVH) and the higher morbidity and mortality related to stroke in this group.
Methods: Participants in the Jackson Cohort of the Atherosclerotic Risk in Communities study who had an echocardiogram during the third cycle from 1993–1996 were followed for incident stroke events.
Results: Of the 2,445 participants who had a baseline echocardiogram, 1,908 had adequate M-mode for assessing LVMI and were free from prevalent stroke (n=70) and LV aneurysm. Over a 7.8 year follow-up, 105 incident stroke events occurred (age-adjusted incidence rate of 7.44 per 1,000 person-years). Compared to those without incident stroke, participants with incident stroke were more hypertensive (89.4% vs. 58.9%) and were more likely diabetic (44.2% vs. 21.3%). LVH was more prevalent in those with incident stroke events (58.1 % vs. 36.4%). LVMI was significantly associated with incident stroke after adjusting for age, sex, diabetes, systolic blood pressure, hypertension, smoking, and total/HDL cholesterol ratio (HR per LVMI quartile increment 1.23; 95%CI 1.0, 1.51).
Conclusion: To the best of our knowledge, this is the first large population-based cohort study of African Americans assessing LVMI relation to incident stroke. We found that after adjusting for known clinical risk factors, echocardiographic LVMI is an independent predictor for incident stroke in this high risk group.