Abstract 3870: Ethnical/Racial Differences in Prevalence of Congestive Heart Failure and their Relation to Serum Vitamin D Concentrations among American Elderly
Introduction: It is estimated that 4.9 million Americans live with congestive heart failure (CHF), and 550,000 new cases are diagnosed yearly. Elderly individuals are at particular high risk of developing CHF. Although experimental evidence is emerging that that dietary factors play an important role in the development of CHF, few studies were carried out to examine micronutrients in relation to CHF.
Hypothesis: We aimed to test the hypothesis that decreased serum vitamin D concentration is associated with increased risk of CHF, and this association, at least, partly explains the health disparity of CHF in African Americans (AA) and Mexican Americans (MA).
Methods: A cross-sectional analytical study was conducted in a sample of 5,018 (White: 3035; AA: 985, and MA: 998) aged 60 or older participating in the third National Health and Nutrition Examination Survey (1988–94).
Results: Prevalence of CHF was 7.8% in White, 9.3% in AA, and 12.6% in MA (p<0.001). Mean (SD) serum vitamin D concentrations were 28.2 (10.3) ng/mL in White, 20.9 (9.9) ng/mL in AA and 24.1 (9.8) ng/mL in MA (ANOVA test: p<0.001). Significant differences in other nutrients (folate, vitamin E, vitamin C) and inflammatory factors (C-reactive protein and homocysteine) were observed among the three ethical/racial population samples. After adjusting for age, race and other covariates, logistic regression analyses indicated that odds ratios (95%CI) of decreased vitamin D per 10 ng/mL were in relation to 1.2 (1.0–1.4) times higher risk of CHF in men and 1.3 (1.1–1.5) in women. The elderly in the lowest quartile for vitamin D (<18 ng/mL) had 2.3 times higher risk of CHF than those in the highest quartile (>=32 ng/mL), and the associations were independent of other covariates.
Conclusion: By using a national representative population sample, the results indicate that decreased serum vitamin D concentration is significantly associated with increased risk of CHF. Lower serum vitamin D levels among African American and Mexican American as compared to White may partly explain the health disparity of CHF among the minority populations.