Abstract 3850: The Ratio of Polyunsaturated to Saturated Fatty Acids in the Serum is a Strong Determinant of the Presence of Coronary Calcification Among US White and Japanese Men Aged 40–49
Background and Purpose: We have previously reported that in men aged 40 – 49 US Whites had significantly higher prevalence of coronary calcification (coronary calcium score (CCS) ≥ 10) than the Japanese; the difference remained after adjusting for traditional and other risk factors. We examined the association of serum fatty acids with coronary calcification in each population and whether serum fatty acids explain the difference in coronary calcification between the two populations.
Methods: We examined 547 randomly selected men aged 40 – 49 form population-based samples: 249 US Whites and 298 Japanese in Japan. Exclusion criteria included those with clinical cardiovascular disease and on lipid medications. CCS was evaluated using electron beam tomography with the Agatston method at both centers. Scans were read centrally by a trained reader. Blood samples including serum fatty acids were analyzed centrally. We made tertile groups of fatty acids by race and performed logistic regression analyses with the low tertile as a reference.
Results: US whites as compared to the Japanese had a more favorable or similar profile of many risk factors including blood pressure (BP), TC, LDL-C, triglycerides (TG), smoking, and fasting glucose. Although serum percentages of marine derived n3 fatty acids were substantially lower in US Whites than in the Japanese, these fatty acids did not show significant associations with coronary calcification (Table⇓). In both US Whites and the Japanese, the ratio of polyunsaturated to saturated fatty acids showed significant inverse associations with coronary calcification. The association remained after adjusting for age, BMI, BP, LDL-C, TG, HLD-C, glucose, insulin, and smoking (Table⇓). PS ratio, however, did not explain the difference in coronary calcification between the two populations.
Conclusion: PS ratio is a strong determinant of the presence of coronary calcification both in US Whites and the Japanese in Japan.