Abstract 3785: Comparison of Plaque Characteristics Between Stable Angina and Acute Coronary Syndrome: A Virtual Histology Intravascular Ultrasound Analysis of Culprit/Target Lesions
Using virtual histology (VH) intravascular ultrasound (IVUS), we compared the plaque compositions of the culprit/target lesions between acute coronary syndrome (ACS) and stable angina pectoris (SAP). Two-hundred four patients (79 ACS patients and 125 SAP patients) underwent VH-IVUS study of the culprit/target lesions for evaluation of plaque characterization. In qualitative VH-IVUS analysis, atheromatous plaques characteristic were divided into 4 types; fibrotic, fibrofatty, dense calcium and necrotic core. Quantitative VH-IVUS measurements were performed at lesion segments with largest necrotic core burden. Thin cap fibroatheroma (TCFA) was defined as necrotic core > 10% without evident overlying fibrous tissue and percent atheroma area > 40% in at least 3 consecutive frames. Results are shown in Table⇓.
In conclusion, compared with SAP patients, plaque area was larger in ACS patients because of positive coronary remodeling. Absolute area of necrotic core was significantly larger in the culprit lesions of ACS patients than in the target lesions of SAP patients. TCFA was more frequently observed in ACS patients than in SAP patients.