Abstract 3716: Progression of Coronary Atherosclerosis at Five-Year Follow-Up: Medical, Angioplasty or Surgery Study (MASS II) Trial
Introduction: A direct relation exists between the number of arteries involved and coronary disease morbidity and mortality. Progression of coronary atherosclerosis is frequently observed in clinical practice, and it is used as an end point in clinical trials; however, its prognostic significance is unclear. In this study, we compared the progression of CAD among the 3 forms of treatment of CAD: surgery (CABG), angioplasty (PCI), and medical treatment (MT).
Methods: An initial angiogram was performed, and after 5-year follow-up in 392 patients, progression was defined as an increased diameter of stenosis ≥15%.
Results: A total of 392 patients randomly assigned to either CABG (136), PCI (n=146), or medical treatment (n=110) were analyzed. The progression of CAD was less in the surgical group compared with that in the PCI or MT group (P0.001). In the PCI group, LAD territory had =greater progression. Among the factors related to more progression regardless of type of treatment, we observed more progression in the group with higher LDL (P=0.03), in the group that did not have angina (P=0.024), and in the group that used more nitrate (P=0.001). There is no relation between progression and events.
Conclusion: In this study, we observed that the risk factors related to progression were LDL and the type of treatment (surgery group).