Abstract 3673: The relationship Between TMP Grades After Primary PCI and Myocardial Damage and Viability in AMI
Background: TIMI myocardial perfusion grade (TMPG) in acute myocardial infarction has been associated with short- and long-term clinical outcomes. The aim of this study was to evaluate the relationship between TMPG and microvascular integrities and myocardial viability.
Methods: Thirty-nine patients (56±11 years) undergoing primary PCI for ST-elevation myocardial infarction (STEMI) were studied. After PCI, we assessed coronary flow reserve (CFR), diastolic deceleration time (DDT), hyperemic microvascular resistance index (hMVRI) by intracoronary (IC) Doppler wire and coronary wedge pressure (Pcw), Pcw/mean aortic pressure(Pa) by IC pressure wire. We performed FDG-PET scan at 7 days after primary PCI. The study patients were divided into three groups according to TMPG (TMPG 0/1: n=16, TMP 2: n=13, TMPG 3: n=10).
Results: There were not significant differences in reperfusion times and cardiac enzymes among the groups. After PCI, the patients achieved TMPG 3 had the most favorable microvascular integrity indexes and FDG uptake rate (Table⇓). There was significant difference in the incidence of the patients with viable myocardium among the groups (percent of the patients with viable myocardium: TMPG 0/1 vs. TMPG 2 vs. TMPG 3: 25.0% vs. 53.8% vs. 80.0%, p=0.022)
Conclusion: TMPG assessed after primary PCI in STEMI was associated with the degree of preserved microvascular integrity and viable myocardium.