Abstract 3670: A Newly Developed Novel Index for Assessing the Degree of Coronary Stenosis Calculated from Pressure Guide Wire
[Background] Although the measurement of fractional flow reserve (FFR) with a pressure guide wire system is useful to estimate the degree of coronary artery stenosis, it is necessary to take zero balance precisely and pressure drifts during procedure should be taken into account in various situations. Therefore we developed a new index for the assessment of coronary stenosis severity which does not need an absolute value of pressure, and examined whether this index reflect precisely the severity of coronary artery stenosis.
[Methods and Results] Twenty patients with a stenosis in the left anterior descending coronary artery were enrolled in this study. The proximal and distal pressures to the stenois were recorded simultaneously, and the relations between them were analyzed by describing the loop between proximal and distal pressures using a pressure guide wire and Vascular Biology System (Cyber Flow-III). The degree of the linear slope of the loop during diastole was defined as Diastolic Pressure Slope (DPS) Index, which reflect the difference of pressure decrement in proximal and distal site of stenosis relatively. The value of DPS index correlated with the degree of angiographic coronary stenosis inversly (R=-0.81, p<0.001) and FFR positively (R=0.87, p<0.001). Furthermore, the best cut-off value of DPS index for the evaluation of a significant coronary stenosis was 0.75 with the sensitivity and specificity of 90% and 92% respectively
[Conclusion] DPS index is a simple and useful predictor to estimate the degree of structural and functional coronary artery stenosis.