Abstract 3628: Serum Macrophage Inflammatory Protein 1 Beta as a Predictor for Cerebro-Cardiovascular Events in Hypertensive Patients
Background: We designed hospital-based cohort study to evaluate prognostic effects of NOn-invasive Atherosclerotic evaluation in Hypertension (NOAH study). Macrophage inflammatory protein-1β (MIP-1β) is one of the chemokines produced by neutrophils and monocytes/ macrophages. However, the influence of systemic MIP-1β on cardiovascular disease is still unclear. Therefore, we sub-analyzed NOAH study to clarify whether serum MIP-1β level is a predictor for cerebro-cardiovascular events in hypertensive patients.
Methods and Results: The study consisted of 574 patients with essential hypertension (male/female=318/256; mean age=61.8±12.4 years old) were performed between January 1998 and June 2004. We measured serum MIP-1β and high-sensitive CRP by ELISA and assessed the prognostic impact of these methods on stroke and cardiovascular diseases (CVD; ischemic heart disease and heart failure) for outcome. During a mean follow-up period of 38 months, 22 strokes and 22 CVD were recorded. According to concentration of MIP-1β, subjects were divided into equal four groups (6.9 – 67.8, 68.1–120.6, 120.6–206.7, 207.4–3062.3 ng/mL, respectively). High-sensitive CRP, blood pressure and age showed no differences among each group. Kaplan-Meier analysis revealed higher stroke and CVD events in patients with highest quartile of MIP-1β (p<0.05 by Logrank test, Fig. 1⇓). Moreover, highest quartile of MIP-1β is an independent predictor by Cox’s hazard model including age, blood pressure and high-sensitive CRP (p<0.05).
Conclusions: These data suggest that serum MIP-1β level might be a useful predictor for cerebro-cardiovascular events in patients with essential hypertension.