Abstract 3622: Role of Adiponectin and Its Relationship to Procollagen Type I Carboxy-terminal Propeptide in Essential Hypertension
Background: Serum concentration of procollagen type I carboxy-terminal propeptide (PICP) is proved to be a good marker for myocardial fibrosis in hypertension. Adiponectin is a cytokine from adipose tissue and decreased adiponectin level is associated with increased atherosclerosis. However, the role of adiponectin and its relationship to PICP in essential hypertension have never been studied before.
Methods: This study consisted of 188 non-diabetic essential hypertensive patients (mean age 41 ± 7 years, 128 men). All of the patients did not have vascular complications, renal, or liver diseases. Serum concentrations of PICP and adiponectin were measured by enzyme-linked immunosorbent assay. Pulse wave velocity (PWV) assessed by tonometry was used as an index for aortic stiffness.
Results: Adiponectin was significantly correlated with triglyceride (r = −243, p = 0.001), high-density lipoprotein (r = 0.284, p<0.001), insulin (r =−0.169, p = 0.020), and body mass index (r = −0.208, p = 0.004). PICP was significantly correlated with PWV (r = 0.146, p = 0.047). PICP was not correlated with blood pressure, lipid profiles, body mass index, and insulin level. However, PICP was significantly correlated with adiponectin (r = −0.200, p = 0.006). After multivariate analysis, PICP was still significantly correlated with adiponectin (B = −0.220, p = 0.004).
Conclusions: Serum adiponectin levels could be a marker for metabolic syndrome in essential hypertension. Adiponectin was significantly negatively correlated with PICP. Adiponectin probably plays an important role in myocardial fibrosis as well as aortic stiffness in essential hypertension.