Abstract 3584: Metabolic Syndrome is Not a Risk Factor for Hospitalizations in a Chronic Heart Failure Population
Introduction: Metabolic syndrome and obesity are risk factors for the development of coronary heart disease and heart failure. In patients with established heart failure, some studies suggest that a higher body mass index (BMI) results in better outcomes compared to patients with a “healthy BMI”.
Hypothesis: We assessed the hypothesis that patients with metabolic syndrome and heart failure would have greater hospitalizations due to the morbidity of each disease state.
Methods: We sought to characterize the impact of the metabolic syndrome on hospitalizations in our outpatient heart failure population. Metabolic syndrome was defined as three or more of the following five components: high triglycerides (≥150 mg/dL), low HDL (< 40 mg/dL in males, < 50 mg/dL in females), elevated fasting glucose (≥ 100 mg/dL), elevated blood pressure (≥ 130/85 mmHg), and abdominal obesity (body mass index ≥ 30).
Results: From our database of 302 patients, 135 (45%) patients had metabolic syndrome. Metabolic and non-metabolic syndrome heart failure patients received similar therapy with angiotensin converting enzyme inhibitors, beta blockers, aldosterone antagonists, diuretics, and digoxin. There were no differences in age, etiology, severity of heart failure, or creatinine clearance. Metabolic syndrome patients exhibited lower pro-BNP levels (3,111.72 vs. 4,586.56, p<0.05). Obesity was a major component in 74% of the patients with metabolic syndrome. When analyzing hospitalizations for the past year, there was a trend towards fewer hospitalizations in patients with metabolic syndrome. Further analysis of heart failure hospitalizations and BMI showed that patients with a BMI ≥ 30 had less heart failure admissions (0.79/year vs. 1.04/year, p<0.05) then patients with BMI < 30.
Conclusion: In our outpatient chronic heart failure clinic, there were no differences in age, etiology of heart failure, treatment, or creatinine clearance between metabolic and non-metabolic syndrome patients. In conclusion, metabolic syndrome patients exhibited a trend towards fewer hospitalizations, and this trend revealed significance for patients with BMI ≥ 30. Obesity may therefore have a protective role in certain patients with congestive heart failure.