Abstract 3526: Reduced Systemic Cytokine Response to Implantation of Sirolimus-Eluting Stents in Patients with Stable Coronary Artery Disease
Background: Cytokines are believed to play an important role during the reparative response of the vascular wall following endothelial injury caused by stent implantation. We evaluated circulating levels of s erum interleukin-6 (IL-6), interleukin-1β (IL-1β) and monocyte chemoattractant protein-1 (MCP-1) levels in pa tients undergoing elective implantation of sirolimus-eluting stents (SES) compared to bare metal stents (BMS).
Methods: Eighty-one patients (63 male, aged 61 ± 11 years) with stable angina who underwent elective single vessel PCI were randomized to SES (n=38) or BMS (n=43) implantation. Blood samples were taken before, 48 hours and 1 month after stent implantation in order to evaluate serum levels of IL-6, IL-1β and MCP-1. Results: Baseline circulating biomarkers did not differ significantly between the two groups (p=NS). IL-6, IL-1β and MCP-1 after BMS implantation showed an increase over the study period. In contrast, patients with SES exhibited a reduction to below-baseline values by the end of the first month (Table 1⇓, *: p< 0.05 compared to baseline values).
Conclusions: I n contrast to BMS, the implantation of SES appears to reduce the peri-procedural inflammatory status. This could contribute to the difference in restenosis rate between these 2 types of stents and may play a pathophysiological role in the mechanism of restenosis.