Abstract 3523: Anemia Predicts 2 Years Mortality and Cardiovascular Events in Japanese Patients Undergoing First Elective Revascularization: from the Coronary Revascularization Demonstrating Outcome Study in Kyoto (CREDO-Kyoto)
Introduction: Recent reports have suggested that anemia predicts short- to medium-term prognosis in patients undergoing coronary revascularization.
Hypothesis: Anemia is an independent risk factor for 2 years prognosis after revascularization.
Methods: We have analyzed 9,086 patients who underwent first elective PCI or CABG surgery during 2000–2002 in CREDO-Kyoto registry from 30 institutions. After excluding patients with malignant disease, or in-hospital death, 8,343 patients were analyzed. The lowest quartile of hemoglobin level (male; <12.6 mg/dl, female; <11.0 mg/dl) was defined as anemic. The efficacy of anemia in assessing 2 years outcome such as cardiovascular mortality, all cause mortality and combined end points (all cause death, myocardial infarction, cerebral vascular disease) was evaluated in comparison with standard coronary risk factors by logistic regression analysis (p<0.05).
Result: At baseline, anemic patients had significantly more frequent cardiovascular comorbidities such as old myocardial infarction, history of heart failure, diabetes, peripheral artery disease, prior cerebral vascular disease, end stage renal disease on hemodialysis. Kaplan-Meier analysis indicated significantly higher cardiovascular mortality (6.1% vs. 1.7% at 1000days), all cause mortality (12% vs. 3.1% at 1000 days), and combined events (17.7% vs. 7.3% at 1000days) in anemic patients (Log-Rank test, p<0.05). After adjustment for other potential risk factors, anemia was identified as an independent predictor of 2 years cardiovascular mortality (OR1.84, 95% confidence interval (CI) 1.01–3.37), all cause mortality (OR2.12, 95% CI1.69 – 4.06) and combined hard end points (OR1.72, 95% CI 1.25–2.36) in logistic regression analysis (Table⇓).
Conclusion: Anemia is an independent predictor of 2 years prognosis in patients undergoing first elective revascularization in a Japanese cohort.