Abstract 3491: Decreased Serum Levels of Interferon Gamma Inducible Protein 10 (IP-10) in Acute Myocardial Infarction Patients After Successful Primary Percutaneous Coronary Intervention are Associated with a Smaller Infarct Size
Background: Interferon gamma inducible protein 10 (IP-10) is a CXC chemokine that is transiently induced in ischemia/reperfusion and an appropriate decrease of induced IP-10 in the reperfused heart is important for infarct healing. However, the serum IP-10 level in myocardial infarction (MI) patients with percutaneous coronary intervention (PCI) and its changes with time have never been reported.
Methods: We prospectively studied 23 consecutive patients with first MI who received successful primary PCI within 24 hours. Blood samples were collected after the primary PCI and on days 3, 7 and 28. Changes of the serum IP-10 level between the day of admission and 3 d (delta 3 d IP-10) were examined.
Results: Serum IP-10 level in MI patients changed compared with normal levels and its alteration was statistically significant. The mean value of delta 3 d IP-10 in the better EF group (>56.9%) was -9.0 pg/ml, while it was 28.4 pg/ml in the worse EF group. Delta 3 d IP-10 was significantly correlated with infarct size, as indicated by max creatine kinase (CK). Stepwise multiple regression analysis revealed that delta 3 d IP-10 was an independent predictor for max CK.
Conclusions: These data suggest that decreased serum IP-10 level within 3 days correlate with a smaller infarct size in patients with acute MI who undergo successful primary PCI.