Abstract 3431: Comparison of Coronary Plaque Characteristics Between Diabetic and Non-Diabetic Subjects: An in-vivo Optical Coherence Tomography Study
Background: Diabetes mellitus (DM) is a major risk factor for coronary heart disease. Data from patients following directional coronary atherectomy and in subjects with sudden cardiac death have demonstrated an increased macrophage content and larger necrotic core in subjects with diabetes compared to non-diabetics. Optical coherence tomography (OCT) is a high resolution imaging modality capable of identifying these plaque characteristics. The aim of this study was to compare in-vivo, plaque characteristics between diabetic and non-diabetic subjects using OCT imaging.
Methods: OCT imaging of the angiographically detectable lesions in the culprit vessel was performed in patients undergoing cardiac catheterization. Lipid was semi-quantified as the number of quadrants on the cross-sectional image of a plaque and when present in ≥ 2 quadrants, the plaque was considered a lipid-rich plaque. Fibrous cap thickness was measured at its thinnest part. Thin-cap fibroatheroma (TCFA) were defined as a lipid rich plaque with fibrous cap thickness <65μm. Macrophage density was calculated as the normalized standard deviation of the optical signal within the fibrous cap.
Results: Among 82 plaques from 63 patients, 19 (24%) plaques were from 16 patients with DM. Both groups were similar in their baseline characteristics except for the serum glucose level. No significant differences were noted in plaque characteristics between diabetics and non-diabetics (Table⇓).
Conclusion: There were no significant differences in coronary plaque characteristics including lipid pool, fibrous cap thickness, TCFA, and macrophage density between patients with DM compared to those without DM.