Abstract 3360: Sarpogrelate, a Selective Serotonin Receptor Antagonist, Improves Vascular Function, Oxidative Stress, Insulin Resistance, and Inflammation in Diabetic Patients with Stable Angina
Background: Sarpogrelate HCl is a novel serotonin blocker, and it has potential as an antianginal drug. To clarify the mechanisms of antianginal effects, we evaluated anti-inflammatory, and antioxidant effects of sarpogrelate HCl. We also assessed vascular function and exercise tolerance in diabetic patients with stable angina.
Methods: Thirty patients with type 2 diabetic mellitus (DM) and stable angina were randomized to receive sarpogrelate (sarpogrelate group, 300mg/day, n=15) or not to receive sarpogrelate (control group, n=15). To evaluate vascular function, flow-mediated dilatation (FMD) of brachial artery was measured by using ultrasound system, and pulse wave velocity (PWV) was measured by using oscilometric technique. We assessed exercise tolerance by exercise time (ExT) to ST segment depression of 0.10 mV during a treadmill exercise test. Thiobarbituric acid reactive substance (TBARS), high sensitivity C-reactive peptide (hsCRP), and HOMA-IR were also measured as indexes of oxidative stress, inflammation and insulin resistance. Measurements were performed at baseline, and at 6 and 12 months after the treatments.
Results: At baseline, there were no differences in all parameters between the both groups. After 12 months, FMD and PWV were significantly improved, and ExT was significantly prolonged in the sarpogrelate group (sarpogrelate group: 345 ± 40 to 490 ± 55 sec, p<0.01; control group: 348 ± 46 to 360 ± 41 sec) as compared with the baseline. TBARS was significantly decreased in the sarpogrelate group (sarpogrelate group: 3.51 ± 0.40 to 2.10 ± 0.40 nmol/mL, p<0.01; control group: 3.54 ± 0.46 to 3.52 ± 0.50 nmol/mL). HOMA-IR and hsCRP were also significantly decreased in the sarpogrelate group.
Conclusion: Sarpogrelate HCl, a serotonin blocker, not only improves vascular function (FMD, PWV) and exercise tolerance, but also improves insulin resistance, inflammation and oxidative stress in diabetic patients with stable angina.