Abstract 3338: Long-Term Outcome of Lung and Heart-Lung Transplantation for Primary Pulmonary Hypertension
Background: The long-term outcome of thoracic transplantation for primary pulmonary hypertension (PPH) is unknown. The purpose of this study was to evaluate the long-term outcome of lung and combined heart-lung transplantation for PPH and the effect of our current organ preservation protocol.
Methods: Retrospective chart review of patients receiving single lung, double lung and combined heart-lung transplantation from 1982 to 2006 was performed. 85 consecutive patients (37.1+/−10.1 years old, ranging 15 to 58; 27 males and 58 females) underwent 9 single lung, 28 double lung and 48 combined heart-lung transplantation. From 1994, we have introduced an organ protection protocol including prostaglandin E1 and nitroglycerin injection to the lung at the start of the perfusion of the preservation solution to the donor lung, and controlled reperfusion with terminal warm blood cardioplegia and pulmonople-gia before reperfusion of the heart and lung. From 1982 to 1993, 59 patients (34.8+/−9.4 years old) underwent 7 single lung, 11 double lung and 41 heart-lung whereas from 1994 to 2006, 26 (42.3+/−9.8 years old) underwent 2 single lung, 17 double lung and 7 heart-lung transplantations. There was no significant difference in over-all survival between lung and heart-lung transplantation (p=0.776, Logrank). Over-all survival was significantly better with 1994–2006 period (p=0.015, Logrank). Conclusions: This retrospective study shows no significant difference in the long-term survival between lung and combined heart-lung transplantation for PPH. With our current organ preservation technique, the long-term survival of lung and combined heart-lung transplantation is excellent.