Abstract 3289: Prognostic Value of Platelet Volume Indices in Acute Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention
BACKGROUND: Mean platelet volume (MPV) is a strong predictor of impaired angiographic reperfusion and six-month mortality in STEMI treated with primary PCI. No data are available for other platelet volume indices (PVI) and their impact on long-term prognosis after acute MI.
AIM: To assess the impact of PVI on long-term prognosis in patients treated with primary percutaneous coronary intervention (PCI) in AMI. METHODS: The study enrolled 541 patients who underwent primary PCI in AMI. Admission blood samples were measured for MPV, platelet distribution width (PDW), and platelet large cell ratio (P-LCR). The patients were followed-up a mean period of 26±11 months with regard to cardiac death, non-fatal reinfarction, re-PCI or CABG.
RESULTS: Kaplan-Meier survival analysis showed significantly higher 26-month mortality rate in patients with high MPV (≥11.7fl) than in those with low MPV (<11.7fl) (11.1% vs. 4%, p<0.001). Similarly, patients with high P-LCR (≥35%) died significantly earlier than those with low P-LCR (<35%) (13.7% vs. 5.7%, p=0.0029). High values of PDW (≥ 16fl) were also correlated with higher mortality rate compared to low values of PDW (<16fl) (17.1% vs. 6.3%, p=0.0014). According to Cox proportional-hazards regression, abciximab administration did not influence the model.
CONCLUSIONS: PVI are strong, independent prognostic factors in PCI-treated acute MI and may carry clinical implications.