Abstract 3246: Clinical, Angiographic and Procedural Predictors of Angiographic Restenosis after Drug-Eluting Stent Implantation
INTRODUCTION: Data on predictors of restenosis after drug-eluting stent (DES) implantation from randomized trials and registries are conflicting.
AIM: To identify baseline factors associated with angiographic restenosis in sirolimus-eluting (SES) and paclitaxel-eluting (PES) stents after they have been contemporaneously implanted in comparable lesions.
METHODS: We analyzed 2269 consecutive de novo native coronary artery lesions in 1283 patients treated with DES between March 2003 and March 2005. Restenosis was defined as ≥50% stenosis within the stented segment at follow-up angiography. A multivariate model which included all variables significantly (p<0.05) associated with restenosis at univariate analysis was utilized to identify independent predictors.
RESULTS: There were no significant differences in baseline characteristics between the 674 patients treated with SES and the 609 treated with PES. Follow-up angiography was performed in 70.5% of patients (68.3% in SES and 73.0% in PES, p=0.08). Angiographic restenosis occurred in 140 (16.9%) SES lesions and 129 (16.8%) PES lesions (p=1.0). The results of multi-variate analysis are shown in the Table⇓. Type of DES was not associated with restenosis by uni- or multi-variate analysis.
CONCLUSIONS: Diabetes mellitus, smaller vessels and implantation of multiple stents remain independent predictors of restenosis in DES overall. However, there are differences between SES and PES with female gender but not diabetes predicting restenosis in PES while diabetes remains associated with restenosis in SES.