Abstract 3202: Dipping Status in Untreated Hypertensive Patients According to their Metabolic Syndrome Score
Objectives: There are no availiable data suggesting a possible association between dipping status and metabolic syndrome (MS) components in patients with essential hypertension. The purpose of the present study was to assess any possible relation of nocturnal blood pressure fall to metabolic syndrome score.
Methods: We studied 6596 consecutive untreated patients with essential hypertension (3845 men, mean age 57 years). We evaluated their dipping status with 24h ambulatory BP monitoring (ABMP) and patients were classified according to their abnormal systolic BP (SBP) fall to extreme dippers (EX) (with ≥20% nocturnal SBP fall), Dippers (D) (with ≥10% but <20% fall), non-dippers (ND) (with ≥0% but <10% fall) and reversed dippers (RD) (with <0% fall). Metabolic syndrome diagnosis was based upon Adult Panel Treatment III criteria and patients were statified according to the presence of one (group I), two (goup II), three ( group III), four (group IV) and five (group V) components of the metabolic syndrome.
Results: In all, 2489 patients had MS, with 2043 in group I, 2064 in group II, 1448 in group III, 770 in group IV and 271 in group V. The five groups did not differ in age and male/female ratio. EX pattern was significantly higher in group I (37.8% vs 34.65% vs 19.33% vs 6.42% vs 1.82%, p<0.001), while in group II RD pattern was significantly higher compared to groups I, III, IV and V ( 26.7% vs 19.67%, vs 25%, vs 19.2%, vs 9.41%, p<0.001). Furthermore comparing groups III, IV and V EX pattern was significantly higher in group III (70.11% vs 23.28% vs 6.61% p<0.001). Finally, comparing patients with or without MS, EX pattern was significanlty higher in patients without MS (72.42% vs 27.58% p<0.001) and RD pattern was significantly higher in those with MS (54.63% vs 45.37%, p<0.001).
Conclusions: These findings indicate a significant relation of dipping status to MS score. The pathopysi-ological background and its clinical significance remains to be clarified.