Abstract 3049: Comparison of Angiographic Patterns of In-Stent Restenosis Between Sirolimus- and Paclitaxel-Eluting Stent
Background: Angiographic pattern of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation was known to be different to that after bare metal stent (BMS) implantation. But the different angiographic pattern of ISR and its prognosis between sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) was rarely known.
Objectives and Methods: We evaluated the angiographic pattern of ISR and its clinical restenosis in 177 ISR lesions of 163 consecutive patients previously treated with SES (n=97) or PES (n=80) from February 2003 to April 2005. Clinical restenosis was defined as target lesion revascularization, nonfatal myocardial infarction or cardiac death after hospital discharge.
Results: In angiographic ISR pattern, diffuse ISR was more common in PES implantation (SES vs PES; 23.7% vs 48.7%, p=0.001) mainly because of higher incidence of diffuse intrastent ISR (SES vs PES; 8.2% vs 33.8%, p<0.001) whereas focal ISR was more common in SES implantation (SES vs PES; 76.3% vs 51.3%, p=0.001) mainly because of higher incidence of focal margin ISR (SES vs PES; 27.8% vs 2.5%, p<0.001). But clinical restenosis did not differ between two DES groups at mean interval of 7.53±8.40 months (SES vs PES; 54.6% vs 56.3%; p=0.830).
Conclusion: Angiographic pattern of ISR differed after SES and PES implantation, but their clinical restenosis was similar to both types of DES.