Abstract 3047: Long-term Evaluation of Postangioplasty Systemic Inflammatory and Oxidative Stress Response of Sirolimus-eluting and Bared Metal Stents
Background: Markers of systemic inflammation appear to be a risk factor of restenosis after percutaneous coronary intervention (PCI). We evaluated circulating levels of high sensitive C-reactive protein (hs-CRP), and total peroxides (TP) in patients undergoing elective implantation of sirolimus-eluting stents (SES) compared to bared metal stents (BMS).
Methods: Eighty-five patients (60 male, aged 63 ± 10 years) with stable angina who underwent elective single vessel PCI were randomized to SES (n= 42) or BMS (n= 43) implantation. Blood samples were taken before, 48 hours, 1 and 6 months after stent implantation in order to evaluate serum levels of hs-CRP, and TP.
Results: Baseline circulating biomarkers did not differ significantly between the two groups (p=NS). At 48 hours after PCI, a significant increase of hs-CRP has noted in BMS group. In addition, at 1 and 6-month follow-up period a significant reduction of hs-CRP was detected only in SES group. Similarly, TP showed a significant attenuation after PCI in the SES group, not noted in the BMS group(see Table 1⇓).
Conclusions: SES implantation in stable angina favorably modifies oxidative stress and systemic inflammation response after PCI compared to BMS. These findings may have a key role in the promising SES results in the reduction of restenosis.