Abstract 3035: Relationship Between Carotid Intima-Media Thickness and Arterial Stiffness in Children After Kawasaki Disease
Background: Evidence of premature atherosclerosis and systemic arterial stiffening in patients after Kawasaki disease (KD) is accumulating. We aimed to test the hypothesis that carotid intima-media thickness (IMT), a surrogate marker of atherosclerosis, is associated with systemic arterial stiffness in children after KD.
Methods: A cohort of 72 subjects was studied, comprising 26 KD patients with coronary aneurysms (group I), 24 KD patients with normal coronary arteries (group II) and 22 healthy age-matched children (group III). The carotid IMT, carotid artery stiffness index, brachioradial pulse wave velocity (PWV), fasting total cholesterol, HDL cholesterol, and LDL cholesterol were determined and compared among the 3 groups.
Results: The carotid IMT was related to indices of arterial stiffness, and significant determinants of carotid IMT identified by multivariate analysis. The carotid IMT of both group I (0.41± 0.04 mm) and group II (0.39± 0.04 mm) was significantly greater than that of group III (0.36± 0.04 mm) (p=0.001 and p<0.008, respectively). For the entire cohort, carotid IMT correlated positively with LDL cholesterol (r=0.31, p=0.009), carotid artery stiffness index (r=0.40, p=0.001) and brachioradial PWV (r=0.28, p=0.016), but not with age, body mass index, systemic blood pressure, and HDL and total cholesterol. Multiple linear regression analysis identified carotid artery stiffness index (β = 0.25, p=0.028) and subject grouping (β = −0.39, p=0.001) (model R2=0.29) as significant correlates of carotid IMT.
Conclusion: The increased carotid IMT in children after KD is associated with systemic arterial stiffening.