Abstract 3031: Cardiac Magnetic Resonance Imaging of Right Ventricular Function Predicts Clinical Outcomes in Patients with a Systemic Right Ventricle
Background: Cardiac magnetic resonance imaging (CMR) permits accurate and reproducible quantitative measurements of RV ejection fraction (EF) and volumes. The relation between RVEF and volumes assessed by CMR and prognosis in systemic RV patients has not been examined.
Methods: A retrospective cohort study of systemic RV patients who had CMR between 10/1997 and 1/2006 was performed. The primary outcome of all-cause mortality or cardiac transplantation after CMR was recorded. RVEF, RV end-diastolic volume index (RVEDVI), and end-systolic volume index (RVESVI) were calculated. Kaplan-Meier analysis with the log-rank test was used to compare event-free survival distributions. Cox regression analyses were also done to determine the effect of RVEF and volumes in univariate and multivariate (age- and sex-adjusted) models.
Results: There were 36 systemic RV patients (15M/21F); 20 (55%) with Mustard repair of D-transposition of the great arteries (TGA) and 16 (44%) with congenitally corrected TGA. The mean age was 32.7±6.9 yrs. The mean follow-up was 2.7±1.8 yrs. See Figure⇓ for Kaplan-Meier analysis and Table⇓ for univariate predictors. RVEF was the only independent predictor of outcomes (HR 7.69 [1.16–50.9], p=0.034) after adjustment for age and sex.
Conclusions: Reduced RVEF assessed by CMR is associated with an increased risk of death or transplantation in patients with a systemic RV.