Abstract 3018: Age-Dependent Changes in Left Ventricular Parameters with Normotensive Aging: Application of Cardiovascular Magnetic Resonance to the Framingham Heart Study Offspring Cohort
Objectives: To identify age-dependent changes in left ventricular (LV) and great vessel parameters in a longitudinally followed adult non-hypertensive population.
Methods: 606 (239 M and 367 F; age 37– 89 years) participants in the Framingham Heart Study Offspring Cohort without hypertension (no SBP>140 or DBP>90 mmHg at any cycle visit and no antihypertensive medications) underwent cardiovascular magnetic resonance (CMR) imaging on a 1.5 T Philips CMR scanner using a breath-hold cine steady state free precession sequence. Contiguous short axis images were acquired from LV base to apex. ECG triggered fast spin echo axial images were obtained to assess the great vessels. Data were analyzed separately by sex, indexed (I) for BSA, and the significance of trends among age quartiles (with age increasing from Q1 to Q4) was assessed. Correlation for parameters with age was also assessed.
Results: There were significant declines in LV end diastolic volume, end systolic volume, and stroke volume indices (LVEDVI, ESVI, SVI) with advancing age for both genders (for all p<0.002) [see Table⇓]. There was a slight decline in LV mass index (LVMI) with advancing age in men (p=0.03), but not women. Among women, but not men, there was a significant positive linear correlation between LVEF (ejection fraction) and age (r=0.20, p<0.001). There were significant upward trends in indexed ascending (Asc) (r=0.35, p<0.001 M; r=0.33, p<0.001 W) and descending aorta diameters (DesAoI) (r=0.44, p<0.001 M; r=0.47, p<0.001 W) in both genders.
Conclusions: Using state-of-the-art CMR sequences in this closely followed cohort, we found that normotensive aging is associated with a decline in LV volumes in both genders, but only men displayed a decrease in LVMI with advancing age. An increase in LVEF with age was observed among only women. These data may help elucidate aging related alterations in the cardiovascular system and suggest age and gender adjusted standards should be used when interpreting CMR data.