Abstract 3011: Inflammation and Increased Oxidative Stress Additively Increased Arterial Stiffness in Middle-aged Japanese Men
Backgrounds: Arterial stiffness is notes as a cardiovascular risk. Age and atherogenic factors contribute to increase in arterial stiffness. While not only inflammation but also oxidative stress act as major atherogenic factor, the significance of these factors contributing to increase arterial stiffness and their independencies have not been fully evaluated. The present cross-sectional study was conducted to examine the relationship of brachial-ankle pulse wave velocity (baPWV), a surrogate marker of arterial stiffness, with inflammation and with oxidative stress, and also evaluate the independency of these relationships.
Methods and Results: baPWV and the plasma levels of high-sensitive C-reactive protein (hsCRP) and Malondialdehyde (MDA) were measured in 2313 middle-age Japanese men (43±10 years). Step-wised multiple linear regression analysis demonstrated that logCRP (beta=0.08, p<0.01 ) and logMDA (beta=0.04, p<0.01) independently associate with baPWV even adjusted of age and blood pressure (R-square=0.50). We defined abnormal elevation of hsCRP was > 1.0 mg/L and that of MDA was> 0.5 μmol/ml (the highest quartile range of MDA). General liner model multivariate regression analysis demonstrated that baPWV in the subjects with co-existence of both abnormalities was significantly higher than other three groups (Figure⇓).
Conclusion: Inflammation and increased oxidative stress seems to independently associate with increase in arterial stiffness. Both atherogenic factors may additively contribute to increase in arterial stiffness, at least in part.