Abstract 2999: Gender-Difference in Brain-Natriuretic Peptide (BNP) Reflects Different Cardiac Remodeling
Background: Women are known to exhibit higher BNP levels than men and to have a higher frequency than men of heart failure with normal left ventricular (LV) chamber size. Whether this suspected gender-related difference in LV structure and function can be detected in an apparently healthy population has not been explored.
Aim of the Study: to examine in an asymptomatic primary cardiovascular prevention population the gender difference of left ventricular end-diastolic diameter (LVIDD) and left ventricular mass index (LVMI) in relation to BNP levels.
Methods: A total number of 513 male and 359 female asymptomatic subjects attending the Cardiovascular Disease Prevention Center underwent an echocardiographic exam and a venous blood sampling on the same day for the determination of BNP. LVIDD was measured and LVMI was calculated following the formula of Devereux. The subjects were categorized by BNP: normal < 50 pg/ml; borderline 50–100 pg/ml; abnormal > 100 pg/ml.
Results: Table 1⇓ summarizes the results. Elevated BNP was more common in women and was associated with mass increase, not volume increase as noted in men.
Conclusions: Men tend to remodel with eccentric hypertrophy, women with concentric hypertrophy.