Abstract 2984: Impact of the Metabolic Syndrome on Stroke in Patients Following Surgical and Percutaneous Complete Revascularization Over a 11-Year Follow-up Period
Background: The prevalence of metabolic syndrome (MS), regarded as an important risk factor for coronary artery disease (CAD), is growing. However, the relationship between MS and stroke, particularly in patients with CAD remains unknown. Therefore, we investigated the impact of the MS on stroke in patients who underwent surgical and percutaneous complete revascularization.
Methods: 1836 consecutive patients who underwent complete revascular-ization (653 patients; PCI and 1183 patients; CABG) from 1984 to 1992. Patients were categorized by the presence or absence of MS using the NCEP-ATPIII definition (for obesity we used a body mass index ≥ 25kg/m2). Multivariate Cox proportional hazards regression were used for adjusted (adjusted for age, gender, smoking history, previous myocardial or cerebral infarction, atrial fibrillation, kidney failure, presentation of acute coronary syndrome, LDL cholesterol level, left ventricular ejection fraction, vessel disease, revascularization procedure) analyses for incidence of stroke (fatal and non-fatal).
Results: The progress of 826 (45.0%) patients with MS and 1010 (55.0%) patients without MS was analyzed. The mean follow-up was 11.4 ± 2.9 years. Overall, there were 130 (7.1 %) stroke, and the incidence of stroke was significantly higher in the MS group than that in the no MS group (8.2% vs. 6.1%, HR 1.44; 95%CI 1.02–2.05; P = 0.038).
Conclusion: The presence of MS significantly increased the risks of subsequent incidence of stroke among patients who underwent complete revascularization.