Abstract 2975: Prognosis of Left Ventricular Hypertrabeculation/Noncompaction
Background and objectives: Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality frequently associated with neuromuscular disorders (NMD). From initial case reports, LVHT is assumed to have a poor prognosis. Aim of the study in a cohort of LVHT patients was to assess the long-term prognosis regarding mortality, cardiac and neuromuscular comorbidity and progression of cardiac and neuromuscular disease.
Methods and results: In 86 patients LVHT was diagnosed echocardiographically between June 1995 and December 2004 (21 female, mean age 52 ± 14, range 14 - 94 years). All patients underwent a baseline cardiologic investigation and were invited for a neurologic investigation. A specific NMD was diagnosed in 21, a NMD of unknown etiology in 33, the neurologic investigation was normal in 13 and 19 patients refused. During a mean follow-up of 51 months (range 3 - 106 months) the mortality rate was 5.3%/year. Predictors for an increased mortality were increased age (p= 0.0134), presence of NMD (p = 0.0324), exertional dyspnoea (p = 0.0329), edema (p = 0.0049), heart failure (p = 0.0048), left anterior hemiblock (p = 0.0078) and a left ventricular fractional shortening < 25% (p = 0.0648).
Conclusion: The mortality of LVHT in adult patients is lower than previously thought. Predictors for mortality are increased age, neuromuscular disorder, heart failure, left ventricular dilatation and systolic dysfunction.