Abstract 2908: Left Ventricular Radial Displacement And Rotation is Related With The Diastolic Function In Dilated Cardiomyopathy Patients
Background and Aim: Cardiac motion can be described by three components, i.e. radial displacement (RD) rotation and translation of the left ventricle (LV). The development of new echocardiographic techniques allows us now to evaluate this motion using the 2D-strain method. We examine the cardiac RD, rotation, rotation rate and the diastolic untwisting rate in patients suffering by dilated cardiomyopathy.
Patients: We examined 34 angiographically proven non-ischemic dilated cardiomyopathy (NIDC) patients, aged 52,6 ±13,9 years, LVEF 35.3±5.8% and in 14 healthy volunteers. The LV diastolic function was evaluated by PW-Doppler, while tissue Doppler velocities from the septal and the base lateral wall were obtained. The cardiac RD, rotation and rotation rate was evaluated by speckle echocardiography from the left parasternal short-axis view at the level of the papillary muscles (EchoPac, GE). Rotation and rotation rate was calculated as the average angular displacement of 6 myocardial regions (anterior, anteroseptal, lateral, posterior, inferior and septal)
Results: Patients showed decreased RD (4.4 ± 1.7 vs 6,5±1.6 mm, p=0.001), systolic rotation (−2.6 ±2.5 vs −4.7 ± 1.70, p=0.01 ), systolic rotation rate (−38.6± 18.7 vs −51.7± 22.3 degrees/sec, p=0.04), early (28.1±20 vs 49.9±35.2 degrees/sec, p=0.01 )and late (24.9±13.2 vs 39.7±10.8 degrees/sec, p=0.002 )diastolic untwisting rate compared to the controls. Univariate analysis revelead that the RD but not rotation or rotation rate was correlated with the Early transmitral (PW-Doppler) to E’( mean TDI velocity of the septal and the lateral wall) ratio (r=−0.43, p=0.01 ) an index reflecting the LV filling pressures. Furthermore the rotation rate and the DR was found to correlate with the LV end-diastolic (r=0.37, p=0.01 & r=−0.57, p<0.001) and end-systolic (r=0.37, p=0.01& r=0.60, p<0.001) volumes respectively.
Conclusions: In NIDC patients there is a reduced cardiac radial and rotation movement as well as and diastolic untwisting motion compared to controls. As LV enlarges both RD and rotation decreases while the RD seems to relate with the LV diastolic function.