Abstract 2905: Low Pre-Procedural High-Density Lipoprotein and Death at One Year After Percutaneous Coronary Intervention
Background: Low HDL cholesterol is associated with increased cardiovascular risk, but its prognostic importance after percutaneous coronary interventions (PCI) is not well established.
Methods: We examined 1-year outcomes in 2,092 patients undergoing PCI between 2001 and 2004 at Emory University. Patients were divided into quartiles by HDL level and were followed for 1 year. Using logistic regression, we compared 1-year clinical outcomes according to HDL quartiles after adjusting for demographic and comorbidity factors.
Results: The baseline clinical characteristics were comparable among HDL quartiles except women were less represented in the lower quartiles. Patients in the lowest quartile (HDL mean 30, range 10–34) had a significantly increased rate of death compared to the other quartiles in both bivariate (Table⇓) and multivariate analyses. There was no difference noted with regards to non-fatal myocardial infarction or revascularization. The adjusted hazard ratio of death for the lowest quartile compared to the highest quartile was 3.0 (95% CI: 1.6–5.5), no significant difference was noted among the other quartiles (Figure⇓). No significant differences were noted in any of the outcomes assessed between quartiles 2, 3, and 4.
Conclusion: Low HDL levels (<35 mg/dL) have a significant prognostic value for one-year mortality after PCI.