Abstract 2900: Periodontal Disease and Presence of Coronary Artery Disease in Patients Undergoing Coronary Angiography
BACKGROUND: Periodontitis has been linked to coronary artery disease (CAD) risk, possibly through providing a systemic inflammatory burden. Few studies have evaluated periodontal disease and angiographic measures of atherosclerosis. Coronary angiography is a widely use method for assessment of presence or absence of coronary artery stenosis. The aim of this study was to evaluate the association between periodontal disease and coronary artery disease.
PATIENTS AND METHODS: 466 patients referred for diagnostic coronary angiography were assessed for periodontal disease. All patients underwent a thorough physical examination, routine laboratory testing, cardiac evaluation and dental examination. Periodontal disease and coronary angiograms were scored blindly by a dentist and two cardiologists, respectively. Any coronary stenosis with a diameter reduction of fifty percent or more was considered as CAD. Presence of periodontal disease was defined by clinical measures including using the Community Periodontal Index of Treatment Needs (CPITN) score parameters.
RESULTS: Ninety four patients (77.5%) had CAD assessed by coronary angiography. CAD patients had periodontal disease in 57.9% compared to 41.5% in non-CAD patients (p<0.05). Increasing CPITN scores were associated with higher prevalence of CAD (p<0.05 for trend). After adjustment for age, gender and traditional risk factors for coronary atherosclerosis, periodontal disease remained statistically significant associated with CAD (OR 1.9 95% CI 1.2 - 3.1, p=0.008). Other independent predictors for presence of CAD were male gender, age, and diabetes.
CONCLUSION: The present study suggests an association between periodontal disease and presence of CAD assessed angiographically. This association may be non-causal, but still demonstrates that CAD and periodontal diseases may cluster in particular groups of a population.