Abstract 2643: The Impact of Gender on the Clinical Outcome after Percutaneous Coronary Revascularization: A Report from the ARTS II Trial
Background: Previous studies in the bare metal stent era have shown gender differences in percutaneous coronary interventions (PCI) with more adverse events observed in women. The aim of the current study was to compare the mid-term outcome between males (M) and females (F) treated with PCI in the ARTS II trial.
Methods: In the study were enrolled 607 patients (pts) (465 M and 142 F) with multi-vessel coronary artery disease (54% 3VD and 46% 2VD), treated with CypherTM stent implantation. All pts were clinically followed-up at one, six and twelve months.
Results: Regarding the baseline characteristics, F were older than M (p<0.001), had a higher incidence of diabetes mellitus (p=0.001), hypertension (p=0.011) and obesity (p<0.001) and presented with a worse anginal status. On the other hand F had better ejection fraction (p=0.049) and a lower rate of previous smoking habit (p<0.001). The angiographic and procedural characteristics were similar between the two genders, except that more M were treaded with IIb/IIIa during PCI (p=0.024). In total 2,159 lesions were treated (1,674 in M and 485 in F, mean stents implantated/pt for M vs. F was 3.7±1.6 vs. 3.5±1.5 respectively, p=0.09). There were no differences between the two genders in terms of in-hospital outcome. Furthermore, at one year there were no gender specific differences in the incidence of major adverse cardiac and cerebrovascular events [MACCE: Death, Cerebrovas-cular Accident (CVA), Myocardial Infarction (MI), repeat PCI (RPCI) and coronary artery bypass graft surgery (GABG)] (Table⇓).
Conclusions: Although F treated with PCI in the ARTS II study were older and had more risk factors compared to M, MACCE rate was similar between the two groups during the in hospital and the one-year follow-up period. This may reflect the fact that sirolimus-eluting stent implantation effectively neutralizes the impact of all the major risk factors, which have traditionally hampered the outcome of F pts, when undergoing their first PCI.