Abstract 2602: Race/Ethnic Relationship with Regional Myocardial Function in an Adult Asymptomatic Population for Cardiovascular Disease: A Tagged MRI Study of the MESA Cohort
Introduction Atherosclerosis is the main etiologic determinant of congestive heart failure (CHF) in the U.S, where both CHF morbidity and mortality are race related. The purpose of this study was to evaluate gender and ethnic differences in regional myocardial function in participants of the Multi-Ethnic Study of Atherosclerosis (MESA).
Methods MESA is a prospective, observational study of asymptomatic individuals with no history of cardiovascular events in four ethnic groups (28% African-American, 9.2% Chinese, 33.1% Caucasians and 29.7% Hispanics). In the 1100 participants who underwent cardiac MRI with tissue tagging, peak midwall systolic circumferential strain (Ecc) (a measure of regional myocardial function) was determined by Harmonic Phase Imaging (HARP). Regional myocardial strain was analyzed before and after adjustment for age, gender and systolic blood pressure (SBP).
Results The mean maximum Ecc % (p<0.001, by One-Way ANOVA) for the entire cohort was estimated by region within the myocardium (Anterior, -18.3 ± 0.12; Lateral, -20.5 ± 0.12; Posterior, -13.8 ± 0.13; Septal -16.1 ± 0.12). In the anterior and posterior walls, African-Americans had significantly less shortening/Ecc (p<0.05), than all other ethnic groups, adjusting for age, gender and SBP. In the lateral wall, African Americans show, on average, significantly less shortening/Ecc (p<0.05), only when compared to Chinese, adjusted by age, gender and SBP (Table 1⇓). Overall, women were found to have significantly increased shortening (p<0.05) in almost all regions, except lateral, even after adjusting for age, race and SBP.
Conclusion: In a large population based study, regional myocardial function differs by both gender and ethnic groups even after adjusting for age and SBP. These results partly explain differences in CHF outcomes among different race/ethnic and gender groups with a potential for guiding future early detection and treatment to prevent CHF.