Abstract 2545: Automated Mitral Annular Tracking in The Evaluation of Diastolic Function: From Normal, Hypertension, Hypertrophy to Hypertrophic Cardiomyopathy
Introduction: The objective quantification and parameters of diastolic dysfunction have not yet been well defined. Tissue Doppler imaging (TDI) is now an emerging tool in clinical application, though it is angle-dependent, time consuming and technically difficult. We developed a technique by using automated tracking of diastolic mitral annular displacement (DMAD), which would allow precise, objective, rapid estimation of diastolic function.
Methods: Conventional echocardiography was performed in 60 patients including hypertrophic cardiomyopathy (HCM), hypertensive hypertrophy (H-LVH), early stage hypertension and healthy subjects (n=15, respectively) recruited from the outpatient clinic. The LV mass and ejection fraction data were acquired by M-mode. Patients with heart failure symptoms and signs were also recorded. DMAD was measured offline using a novel tissue-tracking technique (QLab, Philips) from three apical views.
Results: There was significant difference in the degree of DMAD among the four patient groups (P<0.001, Fig A⇓), and there was no significant difference in age and LV EF among these 4 patient groups. LV mass (Linear Regression) correlated inversely with the degree of DMAD (Fig B⇓). DMAD can be used as a useful and convenient tool in the evaluation of diastolic heart failure (Odds Ratio: 0.733, 95% CI: 0.598~0.898 , P=0.003 by logistic regression)
Conclusions: We have demonstrated the ability of DMAD to discriminate HCM from H-LVH and those with early stage hypertension. It is clinically feasible and can accurately quantify diastolic parameters rapidly by using this new technique.