Abstract 2497: Increased Coronary Sinus Blood Temperature Independent of the Extent of Coronary Artery Disease - Correlation With Systemic Inflammation
Recent studies have shown that patients (pts) with single vessel coronary artery disease suffering from acute coronary syndromes (ACS) have increased coronary sinus (CS) blood temperature compared to the right atrium (RA). The aim of this study was to investigate whether there is 1) a difference in CS temperature and C-reactive protein (CRP) between pts with single versus multivessel disease and 2) a correlation between systemic inflammatory indexes and CS temperature.
Methods: We enrolled 53 patients (pts) with ACS, 25 pts with stable angina (SA) and 22 subjects without coronary artery disease. Systemic inflammatory status was assessed by measuring levels of C-reactive protein (CRP). CS and RA blood temperature measurements were performed by a 7F thermography catheter. ΔT was calculated by subtracting the RA from the CS blood temperature.
Results: ΔT was greater in patients with ACS and with SA compared with the control group (0.22 ±0.10°C, 0.18±0.04°C vs. 0.14±0.07°C, p< 0.01 for both comparisons). Eighteen (39.1%) out of 46 patients with multivessel disease had three-vessel disease and 28 (60.8%) had two-vessel disease. From the control group 10 pts (45.5%) had ΔT<0.15°C, although only 4 had ΔT>0.20°C. From the ACS group only 12 pts (22.6%) had ΔT0.15°C. <T between pts with multivessel and single vessel disease were similar (0.23±0.09°C, 0.20±0.12°C, p=0.32). ΔT was greater in pts with multivessel and single vessel disease compared to controls (p=0.01, p<0.04 respectively). CRP between pts with multivessel and single vessel disease were similar (3.03 ±3.53 vs 3.46 ±2.92 mg/L, p=0.64). CRP was greater in pts with multivessel and single vessel disease compared to controls (p=0.04, p<0.01 respectively). A linear correlation was detected between ΔT and CRP in the total study population and in the ACS group alone (R=0.37, p<0.01, R=0.38, p<0.01 respectively)
Conclusions: In pts with ACS an increased heat production is observed in the coronary vascular bed independent of the extent of coronary artery disease. This increase may be attributed to a systemic inflammatory activation. CS blood temperature measurement may provide significant information for the risk stratification of pts with ACS.