Abstract 2494: The Clinical Randomized Study of Autologous Peripheral Blood Progenitor Cell Transplantation by Intracoronary Infusion in Patients with Acute Myocardial Infarction
Purpose: To investigate the effects and safety of autologous peripheral blood progenitor cell transplantation by intracoronory infusion in patients with AMI.
Method: 70 patients (60±10 years old) with AMI were randomized allocated to two groups: the treated group (n=35) received standard drug and PCI thearpy and intracoronory transplantation of peripheral blood progenitor cell (PBPC), the control group (n=35) only received standard drug and PCI thearpy The treated group received 5-day Granulocyte Colony-Stimulating Factor (G-CSF:Filgrastim,300μg) with the dose of 300μg-600μg/day for mobilizing. On the sixth day, 57ml suspend liquid including PBPC was isolated and collected by blood cell separator and then was infused into infarct related artery through over-the-wire balloon center lumen when the balloon was inflated. Side effects and complications related to G-CSF mobilization, isolation, and catheter-based infusion were investigated.Left ventricular function were assessed at six-month follow-up.
Results: 35 cases had finished follow-up in the treated group, while 23 cases in control group. At 6- month follow-up, in the treated group, there was a significant improvement in global left ventricular function ejection fraction (EF) from a baseline of 51.0 % to56.0 %,(P<0.0001);wall motion score index (WMSI) from 1.188to 1.063,(P <0.0001);left end-systolic volume(ESV)from65.1ml to54.8ml,(P=0.007);and left end-diastolic volume(EDV-)from 134.0ml to 116.0ml,(P=0.213); in the control group, there was no significant improvement in EF,WISM,EDV and ESV(P=0.173,0.167,0.193,0.523). Compared with control group, there was a significant improvement in EF from 56.0 to 53.0,(P=0.042),WISM from1.063 to1.125(P=0.021). The incidence of complications relating to mobilization, separating , intracoronary infusion was 37.1%(13/35), 14.3%(5/35), 20.0%(7/35),respectively. No death was observed.
Conclusion: Autologous Peripheral blood progenitor cell transplantation by intracoronary infusion is feasible, and it can improve left ventricular function in the six-month follow-up.