Abstract 2462: Three-Dimensional Gated Reconstructed Images of the Coronary Arteries Based on Rotational Coronary Angiography: First in Human Results
Purpose: To prove the feasibility to deliver high-spatial-resolution three-dimensional (3D) reconstructed angiograms of the coronary arteries in a conventional interventional suite.
Background: Up to now the volumetric reconstruction of contrast field vessel structures based on rotational angiography (RA) has only been available exclusively in cerebral and other non-coronary imaging where the vascular tree is stationery. The main challenge for 3D volumetric reconstruction from rotational coronary angiography is cardiac and respiratory motion. Our group has systematically developed optimized acquisition protocols enabling ECG-gated 3D reconstruction of the coronary vessel structures.
Methods: The method is based on the utilization of RA during continuous injection of contrast agent (CA) for duration of 7.2s. Acquisition parameters such as iso-centering, acquisition trajectory, contrast injection, and breath holding were optimized for this purpose. 22 subsequent patients were enrolled in a study to demonstrate the feasibility of ECG-gated 3D reconstruction of the left and right coronary arteries.
Results: The acquisition protocol was well tolerated by all patients. 24 data sets of the LCA (15) and RCA (9) were successfully reconstructed. A clear visualization of the entire course of the LCA and RCA tree including 1st, 2nd and often even 3rd order vessels could be obtained in all enrolled patients.
Conclusions: In this work we demonstrate the principle feasibility to create isotropic high-spatially resolved volume reconstructions of the coronary arteries from projection data obtained during a single 7.2s rotational run with a single injection of contrast agent.