Abstract 2423: Abdominal Aortic Wall-Thickness by Magnetic Resonance Imaging and Cardiovascular Disease in a Multi-ethnic Population-Based Study
Objective: Autopsy studies have revealed association between the prevalence of cardiovascular disease and atherosclerosis in the abdominal aorta. Magnetic resonance imaging (MRI) has been reported to detect atherosclerotic changes in abdominal and thoracic aortas. In this study, we assessed aortic wall thickness as a measure of aortic atherosclerosis using MRI and investigated its role as a marker of cardiovascular disease.
Methods: Participants aged 30 – 65 years (2,515) underwent high-resolution MRI of the abdominal aorta at 1.5T using a gated, fat-suppressed, double-inversion recovery, T2-weighted sequence. The vessel wall was assessed and wall area was defined as the difference between total vessel area and lumen area. Aortic wall thickness (AWT) was defined as the ratio of wall area to mean aortic circumference. Cardiovascular disease (CVD) was defined as a history of atherosclerotic coronary or cerebrovascular disease. Weighted analyses, logistic regression and nonparametric analyses were performed to evaluate the association of AWT and the prevalence of CVD.
Results: CVD was reported by 112 participants (4.3%). AWT was significantly higher in participants with CVD (P < .001). The median AWT in participants with CVD was 1.85 mm (interquartile range [IQR], 1.63–2.07 mm), whereas in those with no history of CVD was 1.66 mm (IQR, 1.49 –1.84). In multivariate logistic regression analyses, AWT was positively associated with the prevalence of CVD after adjusting for age, sex, ethnicity and history of diabetes, hypertension, hyperlipidemia and smoking (odds ratio, 2.2; 95% confidence interval, 1.4 –3.5; P < .001).
Conclusions: Aortic wall thickness is an independent marker for the prevalence of cardiovascular disease. Further studies examining the potential value of aortic wall thickness as a screening tool of subclinical aortic and cardiovascular atherosclerosis are warranted.