Abstract 2418: Single-dose Atorvastatin Restores Endothelial Function and Brachial Artery Blood Flow in Normocholesterolemic Men Smokers
Background: It is unknown if there are acute effects of hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) on endothelial function in smokers.
Objective and Methods: To evaluate the acute effect of statin administration, we conducted a prospective study to determine the acute effect (24 hours) of single dose atorvastatin (20 mg) on brachial artery endothelial function using vascular ultrasonography (flow-mediated vasodilation) as well as blood flow in normolipidemic smokers and healthy non-smokers.
Results: We studied 10 male smokers, mean age of 42 ± 9 and 10 healthy male non-smokers, mean age of 39 ± 7. Atorvastatin increased brachial artery %FMD in smokers from 4.1 ± 1.4% to 5.7 ± 1.7% (P < 0.0005), whereas we found no significant change after atorvastatin in non-smokers (from 5.8 ± 1.2% to 5.9 ± 1.2%, P = NS) (Figure⇓). The velocity time integral (VTI) also showed a significant increase in smokers 24 hours after taking atorvastatin (from 19 ± 11 cm to 25 ± 12 cm, P < 0.05), whereas no significant change occurred in non-smokers (from 18 ± 9 cm to 19 ± 10 cm, P < 0.05). Baseline brachial artery diameter significantly dilated in smokers after taking atorvastatin compared to before taking atorvastatin (from 4.23 ± 0.5 mm to 4.35 ± 0.4 mm, P < 0.05), but did not change in non-smokers (from 4.26 ± 0.6 mm to 4.31 ± 0.6 mm, P = NS).
Conclusions: Single dose atorvastatin restores brachial artery blood flow as well as endothelial function in normocholesterolemic men smokers within 24 hours. These findings suggest early benefits of statin therapy on endothelial function in smokers.